The two rookies are Mark Stoneman, the 30 year old opening batsman who is almost certain to play in the match. The other new recruit in the team is Mason Crane, the 20 year old leg spinner from Hampshire.
Stoneman has 1,000 runs in first-class cricket this county season, a top score of 197 with three centuries and averaging 58.82.
Talking to BBC Sport, an excited Stoneman said, “It’s been a long road with some ups and downs along the way, so to get the call was quite a release of emotion and something I’m very proud of.”
“There are new challenges ahead and it’s a step into the unknown, but the experience I’ve had on various surfaces against the best Division One bowlers and some overseas players will stand me in good stead,” he said.
Chris Woakes has also been recalled in the squad after recovering from injury suffered in the opening match of the ICC Champions Trophy.
England squad: Joe Root (captain), Ben Stokes (vice-captain), Alastair Cook, Tom Westley, Dawid Malan, Jonny Bairstow, Moeen Ali, Toby Roland-Jones, Stuart Broad, Jimmy Anderson, Steve Finn, Chris Woakes, Liam Dawson.
West Indies squad: Jason Holder (captain), Kraigg Brathwaite (vice-captain), Devendra Bishoo, Jermaine Blackwood, Roston Chase, Miguel Cummins, Shane Dowrich, Shannon Gabriel, Shimron Hetmyer, Kyle Hope, Shai Hope, Alzarri Joseph, Kieran Powell, Raymon Reifer, Kemar Roach.